Thyroid hormones
Two iodine-containing hormones, thyroxine (T4) and triiodothyronine (T3) , that are secreted by the thyroid gland.
They are essential for normal metabolic processes and mental and physical development.
Lack of these hormones, resulting from underactivity of the thyroid gland (hypothyroidism), causes mental and physical slowing, undue sensitivity to cold, slowing of the pulse,
weight gain, and coarsening of the skin (myxoedema). Hypothyroidism may develop in those who have received treatment for an overactive thyroid gland.
If present at birth, lack of thyroid hormones causes mental retardation and stunted growth (the condition of cretinism). Treatment of hypothyroidism is with thyroxine sodium (levothyroxine sodium) or liothyronine; affected babies must be treated promptly for normal development to occur.
Excessive amounts of thyroid hormones in the bloodstream causes thyrotoxicosis , producing a rapid heartbeat, sweating, tremor, anxiety, increased appetite, loss of weight, and intolerance of heat.
Causes include simple overactivity of the thyroid gland (hyperthyroidism), a hormone-secreting tumour of the gland, and Graves' disease , in which there are additional symptoms, including swelling of the neck (goitre), due to enlargement of the gland, and protrusion of the eyes (exophthalmos).
Treatment may be by the use of antithyroid drugs, which interfere with the production of thyroid hormones. Alternatively, radioactive iodine is given by mouth to destroy some thyroid tissue, or part of the thyroid gland is surgically removed.
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